v. t. - To put out of place, order, or rank; to disturb the proper arrangement or order of; to throw into disorder, confusion, or embarrassment; to disorder; to disarrange; as, to derange the plans of a commander, or the affairs of a nation.
v. t. - To disturb in action or function, as a part or organ, or the whole of a machine or organism.
v. t. - To disturb in the orderly or normal action of the intellect; to render insane.